منابع مشابه
Lessons from Mice without Telomerase
T he observation that almost all malignant cancers have telomerase activity has been explained by the assumption that telomerase is crucial for the progression of malignancy. Surprisingly, cells from mice without a functional telomerase RNA gene and no telomerase activity are indistinguishable from normal cells in different transformation and immortalization assays. However, detailed analysis o...
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In most eukaryotic organisms with a linear genome, the telomerase complex is essential for telomere maintenance and, thus, for genomic integrity. Proper telomerase function in stem and germ cell populations counteracts replication-dependent telomere shortening. On the other hand, repression of telomerase expression in most somatic tissues limits the proliferative potential of these cells throug...
متن کاملLife and Cancer Without Telomerase
replication, 5ف bp per end per cell division, demonstrating that in Drosophila telomeric DNA is not neces-Department of Molecular Biology sary to protect an end from degradation (see for exam-without telomeric DNA appear to function normally, there is no deleterious consequence to the organism until the slow erosion due to incomplete replication Telomeres, the physical ends of eukaryotic chro...
متن کاملInfluenza: Can we cope better with the unpredictable?
Seasonal influenza vaccines are unique because they are regularly reformulated and prepared in anticipation of the upcoming influenza season. Selection of vaccine strains occurs in advance of the influenza season, allowing time for vaccine production. Influenza viruses constantly evolve, and mismatches between vaccine strains and circulating strains have occurred in the past, impacting on vacci...
متن کاملMechanisms to cope with arsenic or cadmium excess in plants.
The metalloid arsenic and the heavy metal cadmium have no demonstrated biological function in plants. Both elements are highly toxic and of major concern with respect to their accumulation in soils, in the food-chain or in drinking water. Arsenate is taken up by phosphate transporters and rapidly reduced to arsenite, As(III). In reducing environments, As(III) is taken up by aquaporin nodulin 26...
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ژورنال
عنوان ژورنال: Genome Biology
سال: 2001
ISSN: 1465-6906
DOI: 10.1186/gb-spotlight-20010302-01